Cadherin 5 Protein (CDH5) (His tag)

Produktnummer ABIN7320374

Recombinant Cadherin 5-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für Cadherin 5 Protein (CDH5) (His tag) (ABIN7320374)

Target: Cadherin 5 (CDH5)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 90 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses Cadherin 5 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse VE-Cadherin/CDH5 Protein (His Tag)

Sequenz: Met 1-Ala 592

Produktmerkmale: A DNA sequence encoding the mouse CDH5 (NP_033998.2) extracellular domain (Met 1-Ala 592) was fused with a polyhistidine tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Cadherin 5 (CDH5)

Andere Bezeichnung: VE-Cadherin/CDH5

Hintergrund:

Background: Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

Synonym: 7B4,AA408225,Cd144,VE-Cad,Vec,VEcad,VECD

Molekulargewicht: 63.5 (or 66) kDa

NCBI Accession: NP_033998

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2