Cadherin 12 Protein (His tag)

Produktnummer ABIN7317919

Dieses Recombinant Cadherin 12-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für Cadherin 12 Protein (His tag) (ABIN7317919)

Target: Cadherin 12

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 80 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Cadherin 12 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Cadherin-12/CDH12 Protein (His Tag)

Sequenz: Met 1-Ala 605

Produktmerkmale: A DNA sequence encoding the pro form of human CDH12 (NP_001783.2) extracellular domain (Met 1-Ala 605) was fused with a polyhistidine tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM sodium citrate, 50 mM NaCl, 2 mM CaCl2, pH 6.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Cadherin 12

Andere Bezeichnung: Cadherin-12/CDH12

Hintergrund:

Background: Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subtypes at synapses indicate that individual cadherin subtypes play their own unique role to regulate synaptic activities. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. Cadherin-12 also known as CDH12, is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherin-12 appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Synonym: CDHB

Molekulargewicht: 66 kDa

NCBI Accession: NP_001783