BCL6 Protein (AA 1-150) (His-TRX)

Produktnummer ABIN7317419

Dieses Recombinant BCL6-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für BCL6 Protein (AA 1-150) (His-TRX) (ABIN7317419)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 92 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 1-150

Aufreinigungstag / Konjugat: Dieses BCL6 Protein ist gelabelt mit His-TRX.

Verwendungszweck: Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag)

Sequenz: Met 1-Met 150

Produktmerkmale: A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.

Sterilität: 0.2 μm filtered

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile 20 mM Tris, 10 % glycerol, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Andere Bezeichnung: BCL6/B-cell CLL lymphoma 6

Hintergrund: BCL5;BCL6A;LAZ3;ZBTB27;ZNF51,The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.

Molekulargewicht:

Calculated MW: 34.2 kDa

Observed MW: 33 kDa

Gen-ID: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus