Adenylosuccinate Lyase Protein (ADSL) (His tag)

Produktnummer ABIN7317594

Dieses Recombinant Adenylosuccinate Lyase-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Adenylosuccinate Lyase Protein (ADSL) (His tag) (ABIN7317594)

Target: Adenylosuccinate Lyase (ADSL)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Adenylosuccinate Lyase Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human ADSL/Adenylosuccinate Lyase Protein (His Tag)

Sequenz: Met 1-Leu 484

Produktmerkmale: A DNA sequence encoding the human ADSL (P30566-1) (Met 1-Leu 484) was expressed, with a polyhistidine tag at the N-terminus.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 10 % glycerol, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Adenylosuccinate Lyase (ADSL)

Andere Bezeichnung: ADSL/Adenylosuccinate Lyase

Hintergrund:

Background: Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotides, both of which involve the _-elimination of fumarate to produce either aminoimidazole carboxamide ribotide from SAICAR or AMP from S-AMP. The Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the present of SAICA riboside and succinyladenosine (S-Ado). ADSL defect in different patients is often caused by different mutations to the enzyme.

Synonym: AMPS,ASASE,ASL

Molekulargewicht: 57 kDa

Pathways: Ribonucleoside Biosynthetic Process