HPD Protein (His tag)

Produktnummer ABIN7318119

Dieses Recombinant HPD-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für HPD Protein (His tag) (ABIN7318119)

Target: HPD (4-Hydroxyphenylpyruvate Dioxygenase (HPD))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses HPD Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human HPD/4HPPD Protein (His Tag)

Sequenz: Met 1-Met393

Produktmerkmale: Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase is produced by our E.coli expression system and the target gene encoding Met1-Met393 is expressed with a 6His tag at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 50 mM NaCl, 1 mM DTT, 0.1 mM PMSF, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: HPD (4-Hydroxyphenylpyruvate Dioxygenase (HPD))

Andere Bezeichnung: HPD/4HPPD

Hintergrund:

Background: 4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in high levels of tyrosine concentration in the blood, which can cause mild mental retardation at birth, and degradation in vision as a patient grows older.

Synonym: 4-Hydroxyphenylpyruvate Dioxygenase, 4-Hydroxyphenylpyruvic Acid Oxidase, 4HPPD, HPD, HPPDase, HPD, PPD

Molekulargewicht: 47.1 kDa

UniProt: P32754