CCR5 Protein-VLP

Produktnummer ABIN7199042

Dieses VLP CCR5-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CCR5 Protein-VLP (ABIN7199042)

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Protein-Typ: VLP

Spezies: Human

Quelle: HEK-293 Cells

Produktdetails

Verwendungszweck: Human CCR5 Full Length Protein-VLP (HEK293)

Sequenz: Met 1 - Leu 352

Produktmerkmale: Human CCR5 Full Length Protein-VLP (CC5-H52P3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Leu 352 (Accession # P51681-1).

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: The protein has a calculated MW of 40.5 kDa.

Kommentare:

Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4

Lagerung: -80 °C

Informationen zur Lagerung: -70°C

Antigendetails

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Andere Bezeichnung: CCR5

Hintergrund: Synonyms: CCR5,CMKBR5,CD195,CC-CKR-5,CHEMR13,
Description: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.5 Publications (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.

Molekulargewicht: 40.5 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size