GDF2 Protein (AA 320-429)

Produktnummer ABIN6973076

Dieses Recombinant GDF2-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für GDF2 Protein (AA 320-429) (ABIN6973076)

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: >95 % as determined by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 320-429

Produktmerkmale: Human GDF-2 Protein, Tag Free

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: ACN, TFA in Water

Lagerung: -20 °C

Antigendetails

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Andere Bezeichnung: GDF-2

Hintergrund: Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.

Molekulargewicht: 12.1 kDa

Pathways: Transition Metal Ion Homeostasis