CXCR3 Protein (AA 1-53) (Fc Tag)

Produktnummer ABIN6964153

Produktdetails

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-53

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CXCR3 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human CXCR3 with C-terminal human Fc tag

Spezifität: CXCR3 (Met1-Arg53) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Andere Bezeichnung: CXCR3 (CXCR3 Produkte)

Hintergrund: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Molekulargewicht: predicted molecular mass of 32.0 kDa after removal of the signal peptide. The apparent molecular mass of CXCR3-hFc is 35-55 kDa due to glycosylation.

UniProt: P49682