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CCL5 Protein (AA 24-91) (Biotin)

Recombinant CCL5-Protein exprimiert in Escherichia coli (E. coli).
Produktnummer ABIN6952202

Kurzübersicht für CCL5 Protein (AA 24-91) (Biotin) (ABIN6952202)

Target

Alle CCL5 Proteine anzeigen
CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 20
  • 7
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Quelle

  • 32
  • 8
  • 2
  • 1
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Applikation

Cell Migration Assay (CMA)

Reinheit

> 97 % by SDS PAGE
  • Proteineigenschaft

    AA 24-91

    Aufreinigungstag / Konjugat

    Dieses CCL5 Protein ist gelabelt mit Biotin.

    Sequenz

    SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS

    Produktmerkmale

    Biotininylated Recombinant Human CCL5 (Rantes)

    Endotoxin-Niveau

    <0.01 EU per 1μg of the protein by the LAL method

    Biological Activity Comment

    EC50 = 0.25-0.50 nM determined by Migration Assay of recombinant CCR5 containing cells
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  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    12 months from date of receipt, -20 to -70 °C as supplied.
    Suggest to use immediately after reconstitution
    1 month at -20 to -70 °C under sterile conditions after reconstitution.

    Haltbarkeit

    12 months
  • Target

    CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

    Andere Bezeichnung

    CCL5 (Rantes)

    Hintergrund

    Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) (CCL5) is a proinflammatory chemokine that induces migration and activation of leukocytes, as well as implication in HIV infection. It binds to cell surface receptors CCR1, CCR3, CCR4, and CCR5. Its biological effects on leukocyte activation and HIV infection displays dependence on concentration and on the binding of cell surface glycosaminoglycans.

    Molekulargewicht

    10.270 kDa

    UniProt

    P13501

    Pathways

    Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration
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