tau-441 (AA 1-441) protein (His tag)

Produktnummer ABIN6809918

Produktdetails

Target: tau-441

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-441

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: His tag

Reinheit: >90 % as determined by reduced SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH 7.5

Lagerung: -20 °C

Antigendetails

Target: tau-441

Hintergrund: Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

Molekulargewicht: 47.9 kDa

NCBI Accession: NP_005901