Chini, Peclat, Warner, Kashyap, Espindola-Netto, de Oliveira, Gomez, Hogan, Tarragó, Puranik, Agorrody, Thompson, Dang, Clarke, Childs, Kanamori, Witte, Vidal, Kirkland, De Cecco, Chellappa et al.: "CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. ..." in: Nature metabolism, Vol. 2, Issue 11, pp. 1284-1304, (2020) (PubMed).
Target
Fc gamma RIV / CD16-2
Hintergrund
FcgR4(Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma . Also acts as a receptor for the Fc region of immunoglobulin epsilon . Binds with intermediate affinity to both IgG2a and IgG2b . Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions