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SIRT6 Protein (GST tag)

Dieses Recombinant SIRT6-Protein wird in Escherichia coli (E. coli) produziert.
Rockland
Produktnummer ABIN6700537
Hersteller Produkt- Nr.: 009-001-t36s

Kurzübersicht für SIRT6 Protein (GST tag) (ABIN6700537)

Target

Alle SIRT6 Proteine anzeigen
SIRT6 (Sirtuin 6 (SIRT6))

Protein-Typ

Recombinant

Spezies

  • 6
  • 2
  • 2
Human

Quelle

  • 8
  • 1
  • 1
Escherichia coli (E. coli)

Applikation

Western Blotting (WB)

Reinheit

>85%
  • Aufreinigungstag / Konjugat

    Dieses SIRT6 Protein ist gelabelt mit GST tag.

    Hersteller Produkt- Nr.

    009-001-t36s

    Hersteller

    Rockland

    Verwendungszweck

    SIRT6 recombinant protein-GST fusion protein

    Aufreinigung

    Full-length recombinant human SIRT6 was expressed in E. coli cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >85% by densitometry.
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  • Applikationshinweise

    Application Note: SIRT6 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. SIRT6 Protein is suitable for use in Western Blot. Expect a band approximately ~66 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

    Western Blot Dilution: User Optimized

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.2 μg/μL

    Buffer

    SIRT6 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    SIRT6 (Sirtuin 6 (SIRT6))

    Andere Bezeichnung

    SIRT6

    Hintergrund

    Synonyms: SIR2L6, Sirtuin 6, NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6

    Background: SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin (1). SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair (2). SIRT6 Protein is ideal for investigators involved in Signaling Proteins, Cancer, Cell Cycle, and Inflammation research.

    NCBI Accession

    NM_016539
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