MBP/MBL Protein (AA 21-248) (His tag)

Produktnummer ABIN6388179

Dieses Recombinant MBP/MBL-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für MBP/MBL Protein (AA 21-248) (His tag) (ABIN6388179)

Target: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: SDS-PAGE (SDS)

Reinheit: > 90% by SDS-PAGE

Produktdetails

Proteineigenschaft: AA 21-248

Aufreinigungstag / Konjugat: Dieses MBP/MBL Protein ist gelabelt mit His tag.

Sequenz: ETVTCED AQKTCPAVIA CSSPGINGFP GKDGRDGTKG EKGEPGQGLR GLQGPPGKLG PPGNPGPSGS PGPKGQKGDP GKSPDGDSSL AASERKALQT EMARIKKWLT FSLGKQVGNK FFLTNGEIMT FEKVKALCVK FQASVATPRN AAENGAIQNL IKEEAFLGIT DEKTEGQFVD LTGNRLTYTN WNEGEPNNAG SDEDCVLLLK NGQWNDVPCS TSHLAVCEFP I

Endotoxin-Niveau: < 1 EU per 1ug of protein (determined by LAL method)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Andere Bezeichnung: MBL

Hintergrund: MBL2, also known as mannose-binding protein C, belongs to the class of collectins in the C-type lectin superfamily. It is a lectin that is instrumental in innate immunity via the lectin pathway. It recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. It It binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes. This protein has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Also, mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection. Recombinant human MBL2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Molekulargewicht: 25.1 kDa (237aa)

NCBI Accession: NP_000233

UniProt: P11226