Liver Arginase Protein (active Mutant)

Produktnummer ABIN6253489

Dieses Recombinant Liver Arginase-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für Liver Arginase Protein (active Mutant) (ABIN6253489)

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: >90 % (SDS-PAGE)

Produktdetails

Proteineigenschaft: active Mutant

Verwendungszweck: Arginase I (human) (rec.) (highly active)

Spezifität: Full length human arginase I.

Kreuzreaktivität: Human

Produktmerkmale: Full length human arginase I.

Biological Activity Comment: 1.6 ±0.2U/μg protein. One unit is defined as the amount of enzyme that converts 1μmol of L-arginine to L-ornithine and urea per min. at 37°C, pH 9.5 (according to protocol from R.T. Schimke, et al., J. Biol. Chem. 238, 1012 (1963)).

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 μg/μL

Buffer: In 10 mM TRIS-HCl, pH 7.5, containing 1 mM beta-mercaptoethanol, 1 mM MnCl2 and 50 % glycerol.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung:

Short Term Storage: -20°C

Long Term Storage: -80°C

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Andere Bezeichnung: Arginase I

Hintergrund:

EC 3.5.3.1, ARG1, Arginase 1, Type I Arginase, Liver-type Arginase, L-Arginase

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.

Molekulargewicht: 34.7kDa

UniProt: P05089

Pathways: Cellular Response to Molecule of Bacterial Origin