AMBP Protein

Produktnummer ABIN621846

Dieses AMBP-Protein wird in Human exprimiert.

Kurzübersicht für AMBP Protein (ABIN621846)

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Spezies: Human

Quelle: Human

Reinheit: > 98.0 % as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Produktdetails

Produktmerkmale: Human Urinary Trypsin Inhibitor

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a (1mg/ml) solution containing no additives.It is recommended to reconstitute the lyophilized UTI in sterile 18M omega cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lagerung: -20 °C

Antigendetails

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Andere Bezeichnung: Urinary Trypsin Inhibitor

Hintergrund: Ulinastatin is derived from human urine. Introduction: Urinary-Trypsin Inhibitor is a glucoprotein proteinase inhibitor with a molecular weight of about 67,000 derived from human urine which inhibits the activity of trypsin, chymotrypsin, lactate, lipase, hyaluronidase and various pancreatic enzymes. Ulinastatin is effective for acute pancreatitis, chronic recurrent pancreatitis and hemorrhagic, traumatic and endotoxic shocks. Ulinastatin is has strong inhibition effect to various protease, sugar and fat hydrolase. Ulinastatin precursor is proteolytically processed into distinct functioning proteins. Urinary trypsin inhibitor belongs to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. Uristatin gene is located on chromosome 9 in a cluster of lipocalin genes. High levels of Ulinastatin secretion is an early marker of renal tubular involvement and has radical scavenging activity. Bikunin localizes cell membrane. Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma. Ulinastatin particularly interacts with ORF3 protein of hepatitis E virus and in charge for enhancing alpha microglobulin export from the hepatocyte. Synonyms: UTI, Bikunin, Uristatin, Ulinastatin, AMBP, EDC1, HI30, ITIL, IATIL, ITILC, Urinary Trypsin Inhibitor.