Human Papilloma Virus E7 (HPV E7) (AA 1-105), (full length) protein (His tag)

Produktnummer ABIN5714208

Recombinant Human Papilloma Virus E7-Protein exprimiert in Hefe.

Kurzübersicht für Human Papilloma Virus E7 (HPV E7) (AA 1-105), (full length) protein (His tag) (ABIN5714208)

Target: Human Papilloma Virus E7 (HPV E7)

Protein-Typ: Recombinant

Spezies: Human Papillomavirus 18 (HPV-18)

Quelle: Hefe

Applikation: SDS-PAGE (SDS)

Reinheit: > 90 %

Produktdetails

Proteineigenschaft: full length, AA 1-105

Aufreinigungstag / Konjugat: His tag

Sequenz: MHGPKATLQD IVLHLEPQNE IPVDLLCHEQ LSDSEEENDE IDGVNHQHLP ARRAEPQRHT MLCMCCKCEA RIKLVVESSA DDLRAFQQLF LNTLSFVCPW CASQQ

Aufreinigung: SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: Human Papilloma Virus E7 (HPV E7)

Andere Bezeichnung: VE7

Substanzklasse: Viral Protein

Hintergrund: E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassbly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription .

Molekulargewicht: 14 kDa

UniProt: P06788