GPR161 Protein (AA 1-28, Extracellular, partial) (GST tag)

Produktnummer ABIN5712333

Produktdetails

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Protein-Typ: Recombinant

Proteineigenschaft: Extracellular, AA 1-28, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses GPR161 Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MSLNSSLSCR KELSNLTEEE GGEGGVII

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Andere Bezeichnung: GP161 (GPR161 Produkte)

Hintergrund: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown .

Molekulargewicht: 30.4 kDa

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process