ARHGEF7 Protein (AA 1-250, partial) (GST tag)

Produktnummer ABIN5712151

Produktdetails

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-250, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ARHGEF7 Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG RTGWFPSNYV REVKASEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN ILETENEYSK ELQTVLSTYL RPLQTSEKLS SANISYLMGN LEEICSFQQM LVQSLEECTK LPEAQQRVGG CFLNLMPQMK TLYLTYCANH PSAVNVLTEH SEELGEFMET KGASSPGILV LTTGLSKPFM RLDKYPTLLK ELERHMEDYH

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Andere Bezeichnung: ARHG7 (ARHGEF7 Produkte)

Synonyme: BETA-PIX Protein, COOL-1 Protein, COOL1 Protein, Nbla10314 Protein, P50 Protein, P50BP Protein, P85 Protein, P85COOL1 Protein, P85SPR Protein, PAK3 Protein, PIXB Protein, cool1 Protein, p50 Protein, p85 Protein, pak3 Protein, pixb Protein, ARHGEF7 Protein, P85spr Protein, Pak3bp Protein, Cool Protein, PIX Protein, betaPix Protein, betaPix-b Protein, betaPix-c Protein, cool-1 Protein, mKIAA0142 Protein, p85Cool1 Protein, p85SPR Protein, arhgef7 Protein, bbh Protein, bpix Protein, im:7142367 Protein, wu:fc35h08 Protein, zgc:101775 Protein, Rho guanine nucleotide exchange factor 7 Protein, Rho guanine nucleotide exchange factor 7 S homeolog Protein, ankyrin repeat domain 10 Protein, Rho guanine nucleotide exchange factor (GEF7) Protein, Rho guanine nucleotide exchange factor (GEF) 7b Protein, ARHGEF7 Protein, arhgef7.S Protein, arhgef7 Protein, ANKRD10 Protein, Arhgef7 Protein, arhgef7b Protein

Hintergrund: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce mbrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions . May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.3 Publications

Molekulargewicht: 55.7 kDa

UniProt: Q14155

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation