Glyco (AA 20-459) protein (His-SUMO Tag)

Produktnummer ABIN5711133

Produktdetails

Target: Glyco

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-459

Spezies: Rabies Virus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: His-SUMO Tag

Applikation: SDS-PAGE (SDS)

Sequenz: KFPIYTILDK LGPWSPIDIH HLSCPNNLVV EDEGCTNLSG FSYMELKVGY ILAIKMNGFT CTGVVTEAET YTNFVGYVTT TFKRKHFRPT PDACRAAYNW KMAGDPRYEE SLHNPYPDYR WLRTVKTTKE SLVIISPSVA DLDPYDRSLH SRVFPSGKCS GVAVSSTYCS TNHDYTIWMP ENPRLGMSCD IFTNSRGKRA SKGSETCGFV DERGLYKSLK GACKLKLCGV LGLRLMDGTW VAMQTSNETK WCPPDQLVNL HDFRSDEIEH LVVEELVRKR EECLDALESI MTTKSVSFRR LSHLRKLVPG FGKAYTIFNK TLMEADAHYK SVRTWNEILP SKGCLRVGGR CHPHVNGVFF NGIILGPDGN VLIPEMQSSL LQQHMELLES SVIPLVHPLA DPSTVFKDGD EAEDFVEVHL PDVHNQVSGV DLGLPNWGKY

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: Glyco

Substanzklasse: Viral Protein

Hintergrund: Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell mbrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Molekulargewicht: 65.46 kDa

UniProt: P03524