RAN Protein (AA 2-219) (His-SUMO Tag)

Produktnummer ABIN5710886

Produktdetails

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-219

Spezies: Saccharomyces cerevisiae

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses RAN Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: SAPAANGEVP TFKLVLVGDG GTGKTTFVKR HLTGEFEKKY IATIGVEVHP LSFYTNFGEI KFDVWDTAGQ EKFGGLRDGY YINAQCAIIM FDVTSRITYK NVPNWHRDLV RVCENIPIVL CGNKVDVKER KVKAKTITFH RKKNLQYYDI SAKSNYNFEK PFLWLARKLA GNPQLEFVAS PALAPPEVQV DEQLMQQYQQ EMEQATALPL PDEDDADL

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Andere Bezeichnung: GSP1 (RAN Produkte)

Hintergrund: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1.

Molekulargewicht: 40.66 kDa

UniProt: P32835

Pathways: Regulatorische RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus