SMARCA2 Protein (AA 700-1216, partial) (His-SUMO Tag)

Produktnummer ABIN5710378

Produktdetails

Target: SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))

Protein-Typ: Recombinant

Proteineigenschaft: partial, AA 700-1216

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses SMARCA2 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: SYYTVAHAIS ERVEKQSALL INGTLKHYQL QGLEWMVSLY NNNLNGILAD EMGLGKTIQT IALITYLMEH KRLNGPYLII VPLSTLSNWT YEFDKWAPSV VKISYKGTPA MRRSLVPQLR SGKFNVLLTT YEYIIKDKHI LAKIRWKYMI VDEGHRMKNH HCKLTQVLNT HYVAPRRILL TGTPLQNKLP ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGERVDLNEE ETILIIRRLH KVLRPFLLRR LKKEVESQLP EKVEYVIKCD MSALQKILYR HMQAKGILLT DGSEKDKKGK GGAKTLMNTI MQLRKICNHP YMFQHIEESF AEHLGYSNGV INGAELYRAS GKFELLDRIL PKLRATNHRV LLFCQMTSLM TIMEDYFAFR NFLYLRLDGT TKSEDRAALL KKFNEPGSQY FIFLLSTRAG GLGLNLQAAD TVVIFDSDWN PHQDLQAQDR AHRIGQQNEV RVLRLCTVNS VEEKILAAAK YKLNVDQKVI QAGMFDQKSS SHERRAF

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))

Andere Bezeichnung: SMCA2 (SMARCA2 Produkte)

Hintergrund: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a postmitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth .

Molekulargewicht: 75.7 kDa

UniProt: P51531