HDAC1 Protein (AA 1-482, full length) (His-SUMO Tag)

Produktnummer ABIN5709649

Produktdetails

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Protein-Typ: Recombinant

Proteineigenschaft: full length, AA 1-482

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HDAC1 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK LA

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Andere Bezeichnung: HDAC1 (HDAC1 Produkte)

Synonyme: GON-10 Protein, HD1 Protein, RPD3 Protein, RPD3L1 Protein, CG7471 Protein, DHDAC1 Protein, DRpd3 Protein, DmHDAC1 Protein, Dmel\\CG7471 Protein, E(var)3-64BC Protein, HDAC Protein, HDAC-1 Protein, HDAC1 Protein, Hdac1 Protein, Rpd3/HDAC Protein, Su(var)3-26 Protein, Su(var)326 Protein, Su(var)328 Protein, dHDAC-1 Protein, dHDAC1 Protein, dRPD3 Protein, dRpd3 Protein, dmHDA401 Protein, drpd3 Protein, hdac1 Protein, l(3)04556 Protein, l(3)64Cc Protein, rpd3 Protein, rpd[3] Protein, gon-10 Protein, hdac1b Protein, rpd3l1 Protein, Rpd3 Protein, GB14706 Protein, hdac1-b Protein, chunp6919 Protein, hdac-1 Protein, mp:zf637-2-001987 Protein, wu:fb19h11 Protein, wu:fi06f03 Protein, zgc:101582 Protein, zgc:65818 Protein, Hdac1-ps Protein, MommeD5 Protein, ARABIDOPSIS HISTONE DEACETYLASE 1 Protein, ARABIDOPSIS HISTONE DEACETYLASE 19 Protein, ATHD1 Protein, ATHDA19 Protein, ATRPD3A Protein, F20D10.250 Protein, F20D10_250 Protein, HDA1 Protein, HDA19 Protein, HISTONE DEACETYLASE Protein, HISTONE DEACETYLASE 19 Protein, HISTONE DEACETYLASE19 Protein, RPD3A Protein, histone deacetylase 1 Protein, HDM Protein, ab21 Protein, hdac1a Protein, histone deacetylase 1 Protein, Histone deacetylase 1 Protein, histone deacetylase Protein, histone deacetylase 1 S homeolog Protein, histone deacetylase Rpd3 Protein, histone deacetylase 1 L homeolog Protein, HDAC1 Protein, hdac1.S Protein, LOC411503 Protein, hdac1 Protein, Hdac1 Protein, HD1 Protein, hda-1 Protein, hdac1.L Protein, LOC748850 Protein

Hintergrund: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation

Molekulargewicht: 71.1 kDa

UniProt: Q13547

Pathways: Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis