Granulin Protein (GRN) (AA 1-602)

Produktnummer ABIN5564460

Produktdetails

Target: Granulin (GRN)

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-602

Spezies: Ratte

Quelle: HEK-293 Cells

Applikation: SDS-PAGE (SDS)

Verwendungszweck: Progranulin (rat) (rec.) (untagged)

Kreuzreaktivität: Ratte

Produktmerkmale: Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional aa.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg purified protein (LAL test).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Contains PBS.

Handhabung: After reconstitution, prepare aliquots and store at -20 °C. Centrifuge lyophilized vial before opening and reconstitution. Do not freeze/thaw. PBS containing at least 0.1 % BSA should be used for further dilutions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: Granulin (GRN)

Andere Bezeichnung: Progranulin (GRN Produkte)

Hintergrund:

Proepithelin, PEPI, PC Cell-derived Growth Factor

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Molekulargewicht: ~73kDa (SDS-PAGE)