Granulin Protein (GRN) (AA 1-593)

Produktnummer ABIN5564456

Produktdetails

Target: Granulin (GRN)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 1-593

Spezies: Human

Quelle: HEK-293 Cells

Applikation: SDS-PAGE (SDS)

Verwendungszweck: Progranulin (human) (rec.) (untagged)

Kreuzreaktivität: Human

Produktmerkmale: Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.

Reinheit: >98 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg purified protein (LAL test).

Biological Activity Comment: Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Contains PBS.

Handhabung: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: Granulin (GRN)

Andere Bezeichnung: Progranulin (GRN Produkte)

Hintergrund:

Proepithelin, PEPI, PC Cell-derived Growth Factor

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is also a functional signaling receptor for progranulin as reported recently.

Molekulargewicht: ~74kDa (glycosylated protein by SDS-PAGE)

UniProt: P28799