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SNCA Protein (full length)

Name: SNCA Protein (full length)
Brand: antibodies-online
SKU: ABIN5065824
Price: 926.25 EUR
Availability: InStock

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 92% pure using SDS-PAGE analysis. SDS, WB, in vitro, in vivo Active

SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Aggregate (Control) . (SNCA Protein (full length))

SDS

Evaluation of a-syn toxicity on primary mouse cortical neurons. (SNCA Protein (full length))

Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers . (SNCA Protein (full length))

Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Aggregate at 4 µg/ml (D-F), but not when treated with control Alpha Synuclein Protein Aggregate at 4 µg/ml (A-C). (SNCA Protein (full length))

IF/ICC

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5065824) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5065824). (SNCA Protein (full length))

Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Pre-formed Fibrils (ABIN5065824) at 4 μg/mL (D-F), but not when treated with Type 2 Alpha Synuclein Pre-formed Fibrils (ABIN5065824) at 4 μg/mL (A-C). (SNCA Protein (full length))

Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) (Catalog No. (SNCA Protein (full length))

TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065824) (SNCA Protein (full length))

8 Abbildungen

Produktnummer ABIN5065824

Datenblatt (PDF)

Target Alle SNCA Proteine anzeigen

SNCA (Synuclein, alpha (SNCA))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Proteineigenschaft

full length
Spezies
29

7

4

2

1

1

1

1

1

1

1

1

1

1
Human
Quelle
26

13

5

2

2
Escherichia coli (E. coli)

Applikation

SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)

Sequenz

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Spezifität

~14.46 kDa

Aufreinigung

Ion-exchange Purified

Reinheit

92% pure using SDS-PAGE analysis.

Biological Activity Comment

Does not induce Lewy body inclusion formation in Sprague-Dawley rat primary hippocampal neurons. Thioflavin T emission curve shows only a small increase in fluorescence (indicative of alpha synuclein aggregation) when Type 2 alpha synuclein PFFs (SPR-317) are combined with alpha synuclein monomers (SPR-321 or SPR-316). Certain biological activities in other neuronal cells cannot be ruled out. Researchers should test compatibility prior to use.

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Applikationshinweise

Optimal working dilution should be determined by the investigator.

Kommentare

Certified 92% pure using SDS-PAGE analysis.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

Lot specific

Buffer

PBS pH 7.4

Lagerung

-80 °C
Target

SNCA (Synuclein, alpha (SNCA))

Andere Bezeichnung

Alpha Synuclein (SNCA Produkte)

Hintergrund

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

Molekulargewicht

14.46 kDa

Gen-ID

6622

NCBI Accession

NP_000336

UniProt

P37840

Pathways

Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity