IgA1 Protein

Produktnummer ABIN3119703

Dieses Native IgA1-Protein wird in Human produziert.

Kurzübersicht für IgA1 Protein (ABIN3119703)

Target: IgA1

Protein-Typ: Native

Spezies: Human

Quelle: Human

Reinheit: > 95 %

Produktdetails

Verwendungszweck: Immunoglobulin A1, Human Plasma (IgA1)

Produktmerkmale: Human plasma-derived IgA.
The predominant IgA subclass in circulation, comprising 90% of total serum IgA. It functions as a pathogen neutralizer, immune complex clearance facilitator, and cytoxicity mediator.

Anwendungsinformationen

Applikationshinweise: For use in: IsoC

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.

Lagerung: -80 °C

Informationen zur Lagerung: -70°C or lower

Antigendetails

Target: IgA1

Andere Bezeichnung: Immunoglobulin A1

Hintergrund: Serum IgA1 is the predominant subclass of Immunoglobulin A in human circulation, comprising approximately 90% of total serum IgA. It eatures a distinctive hinge region with multiple O-linked glycans, distinguishing it structurally from IgA2. IgA1 serves critical immune functions by neutralizing pathogens, facilitating immune complex clearance, and mediating antibody-dependent cell-mediated cytotoxicity through FcαRI receptors on neutrophils and monocytes.
Aberrant glycosylation of IgA1 plays a central role in IgA nephropathy pathogenesis, where galactose-deficient IgA1 forms immune complexes that deposit in glomeruli, triggering kidney inflammation and damage. Additionally, IgA1 abnormalities are implicated in IgA vasculitis, celiac disease, and certain autoimmune conditions.