MMP8 Protein (full length)

Produktnummer ABIN2965548

Dieses Recombinant MMP8-Protein wird in exprimiert.

Kurzübersicht für MMP8 Protein (full length) (ABIN2965548)

Target: MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

Protein-Typ: Recombinant

Spezies: Human

Wirt: Bitte anfragen

Applikation: Activity Assay (AcA), Standard (STD)

Reinheit: > 90 % as determined by SDS-PAGE.

Produktdetails

Proteineigenschaft: full length

Produktmerkmale: Recombinant Human Matrix Metalloproteinase-8

Anwendungsinformationen

Applikationshinweise: Used as a standard for analyzing mammalian collagenase activity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The protein Solution (100 units/ml) in 0.05M Tris-HCl buffer, pH 7.6, containing 0.2M NaCl, 5mM CaCl2, 0.0025% NaN3 and 0.1% BSA.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Antigendetails

Target: MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

Andere Bezeichnung: Matrix Metalloproteinase-8

Hintergrund: Matrix Metalloproteinase-8 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 75 kDa. The MMP-8 is purified by proprietary chromatographic techniques. Introduction: Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation. Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes. Synonyms: Neutrophil collagenase, EC 3.4.24.34, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL, HNC, CLG1.