KIF13A Protein

Produktnummer ABIN2746815

Produktdetails

Target: KIF13A (Kinesin Family Member 13A (KIF13A))

Protein-Typ: Recombinant

Spezies: Human, Maus, Ratte

Quelle: Escherichia coli (E. coli)

Applikation: Positive Control (PC), Western Blotting (WB)

Verwendungszweck: Purified Protein in ready-to-use SDS sample buffer.

Aufreinigung: Purified Protein

Anwendungsinformationen

Applikationshinweise: The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.

Kommentare:

Synonyms: anti-Kinesin family member 13A antibody, kinesin-like protein RBKIN

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.

Lagerung: -20 °C

Informationen zur Lagerung: -20 °C for long term storage

Antigendetails

Target: KIF13A (Kinesin Family Member 13A (KIF13A))

Andere Bezeichnung: KIF13A (KIF13A Produkte)

Synonyme: KIF13A Protein, RBKIN Protein, bA500C11.2 Protein, 4930505I07Rik Protein, mKIAA4109 Protein, kinesin family member 13A Protein, kinesin-like protein KIF13A Protein, KIF13A Protein, LOC534832 Protein, Kif13a Protein

Hintergrund: KIF13A- selective antibodies were generated The kinesin superfamily of proteins (also known as KIFs) constitutes a large family of over forty KIF microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, mitotic spindle formation, chromosome segregation, cytokinesis, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF13A is a subfamily of Kinesins that is expressed essentially in the central nervous system in early developmental stages. It functions in positioning of endosomes and directs mannose-6-phosphate receptor-(M6PR) containing vesicles from the trans-Golgi network to the plasma membrane. KIF13A is an end-directed microtubule-dependent motor protein which associates with β1-adaptin, a subunit of the AP-1 adaptor complex. Overexpression of KIF13A results in mislocalization of the AP-1 (Activator Protein 1) and the M6PR. Functional blockade of KIF13A reduces cell surface expression of the M6PR. Thus, KIF13A transports M6PR-containing vesicles and targets the M6PR from TGN to the plasma membrane via direct interaction with the AP-1 adaptor complex. Studies have identified three Kinesin-3 family members-KIF1A, KIF13A, and KIF13B that interact with dendritic vesicle populations to evaluate motor-vesicle interactions in living cells. Mutations in KIF13A gene are associated with occurrence of schizophrenia.

Molekulargewicht: 217 kDa

NCBI Accession: NP_071396

UniProt: Q9H1H9