AADAT Protein (His tag)

Produktnummer ABIN2745733

Produktdetails

Target: AADAT (Aminoadipate Aminotransferase (AADAT))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses AADAT Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Verwendungszweck: Kynurenine Aminotransferase II (human) (rec.) (His)

Kreuzreaktivität: Human

Produktmerkmale: Human full-length KAT II is fused at the N-terminus to a His-tag.

Reinheit: >97 % (SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).

Handhabung: After opening, prepare aliquots and store at -80 °C. Avoid freeze/thaw cycles.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung:

Short Term Storage: -20°C

Long Term Storage: -80°C

Use & Stability: Stable for at least 6 months after receipt when stored at -80°C.

Haltbarkeit: 6 months

Antigendetails

Target: AADAT (Aminoadipate Aminotransferase (AADAT))

Andere Bezeichnung: Kynurenine Aminotransferase II (AADAT Produkte)

Hintergrund:

hKAT II, KAT2, alpha-Aminoadipate Aminotransferase (Mitochondrial), AADAT, EC 2.6.1.7

Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.

Molekulargewicht: ~49.8kDa