WRAP53 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2735538

Dieses Recombinant WRAP53-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für WRAP53 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2735538)

Target: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Antibody Production (AbP), Standard (STD)

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Produktdetails

Proteineigenschaft: Transcript Variant 2

Aufreinigungstag / Konjugat: Dieses WRAP53 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Produktmerkmale:

• Recombinant human WDR79 / TCAB1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Andere Bezeichnung: Wdr79,tcab1

Hintergrund: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.

Molekulargewicht: 59.1 kDa

NCBI Accession: NP_001137462

Pathways: Telomere Maintenance