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SLIT2 Protein

Dieses Recombinant SLIT2-Protein wird in HEK-293 Cells exprimiert.
Produktnummer ABIN2732203

Kurzübersicht für SLIT2 Protein (ABIN2732203)

Target

Alle SLIT2 Proteine anzeigen
SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 9
  • 3
  • 3
Human

Quelle

  • 9
  • 3
  • 1
  • 1
  • 1
HEK-293 Cells

Applikation

Antibody Production (AbP), Standard (STD), Functional Studies (Func), Protein Interaction (PI)

Reinheit

> 95 % as determined by SDS-PAGE and Coomassie blue staining
  • Spezifität

    Optimal preservation of protein structure, post-translational modifications and functions.

    Produktmerkmale

    • Recombinant human SLIT2 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.

    Endotoxin-Niveau

    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).

    Biological Activity Comment

    Determined by its ability to inhibit MC3T3/E1 osteoblasts cell differentiation.
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  • Applikationshinweise

    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2

    Handhabung

    Resuspend the protein in the desired concentration in proper buffer

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target

    SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

    Andere Bezeichnung

    Slit2

    Hintergrund

    This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants.

    Molekulargewicht

    120 kDa

    NCBI Accession

    NP_004778

    Pathways

    Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration
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