Nicastrin Protein (NCSTN) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2727295

Dieses Recombinant Nicastrin-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für Nicastrin Protein (NCSTN) (Myc-DYKDDDDK Tag) (ABIN2727295)

Target: Nicastrin (NCSTN)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Antibody Production (AbP), Standard (STD)

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Produktdetails

Aufreinigungstag / Konjugat: Dieses Nicastrin Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Produktmerkmale:

• Recombinant human Nicastrin protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: Nicastrin (NCSTN)

Andere Bezeichnung: Nicastrin

Hintergrund: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProtKB/Swiss-Prot Function]

Molekulargewicht: 75.2 kDa

NCBI Accession: NP_056146

Pathways: Notch Signalweg, Neurotrophin Signalübertragung