MCFD2 Protein (Myc-DYKDDDDK Tag)
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- Target Alle MCFD2 Proteine anzeigen
- MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses MCFD2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human MCFD2 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product MCFD2 Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))
- Andere Bezeichnung
- Mcfd2 (MCFD2 Produkte)
- Synonyme
- hm:zeh1186 Protein, wu:fc23b10 Protein, wu:fd50d08 Protein, zgc:103713 Protein, zgc:109915 Protein, MCFD2 Protein, DKFZp469B098 Protein, F5F8D Protein, F5F8D2 Protein, LMAN1IP Protein, SDNSF Protein, 1810021C21Rik Protein, F5f8d Protein, Lman1ip Protein, Sdnsf Protein, multiple coagulation factor deficiency 2 Protein, multiple coagulation factor deficiency 2 L homeolog Protein, MCFD2 Protein, mcfd2 Protein, mcfd2.L Protein, Mcfd2 Protein
- Hintergrund
- This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1 also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D) a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Molekulargewicht
- 13.5 kDa
- NCBI Accession
- NP_644808
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