MBNL1 Protein (Transcript Variant 5) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2725581

Dieses Recombinant MBNL1-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für MBNL1 Protein (Transcript Variant 5) (Myc-DYKDDDDK Tag) (ABIN2725581)

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Antibody Production (AbP), Standard (STD)

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Produktdetails

Proteineigenschaft: Transcript Variant 5

Aufreinigungstag / Konjugat: Dieses MBNL1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Produktmerkmale:

• Recombinant human MBNL1 (transcript variant 5) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Andere Bezeichnung: Mbnl1

Hintergrund: This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.

Molekulargewicht: 34 kDa

NCBI Accession: NP_997178

Pathways: Ribonucleoprotein Complex Subunit Organization