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MKRN1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

MKRN1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2725233
  • Target Alle MKRN1 Proteine anzeigen
    MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Transcript Variant 1
    Spezies
    • 3
    • 1
    • 1
    Human
    Quelle
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses MKRN1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human Makorin-1 (transcript variant 1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product MKRN1 Protein
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))
    Andere Bezeichnung
    Makorin-1 (MKRN1 Produkte)
    Synonyme
    MKRN1 Protein, MGC84269 Protein, mkrn1 Protein, Makorin-1 Protein, RNF61 Protein, RFP Protein, makorin ring finger protein 1 Protein, E3 ubiquitin-protein ligase makorin-1 Protein, makorin ring finger protein 1 S homeolog Protein, makorin, ring finger protein, 1 Protein, MKRN1 Protein, LOC100393879 Protein, mkrn1.S Protein, Mkrn1 Protein
    Hintergrund
    This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein&aposs E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Molekulargewicht
    53.2 kDa
    NCBI Accession
    NP_038474
    Pathways
    Chromatin Binding
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