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BMP4 Protein (Bone Morphogenetic Protein 4) (Transcript Variant 1)

BMP4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD Active
Produktnummer ABIN2715301
$388.80
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
10 μg
Lieferung in 4 bis 8 Werktagen
  • Target Alle BMP4 Proteine anzeigen
    BMP4 (Bone Morphogenetic Protein 4 (BMP4))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    Transcript Variant 1
    Spezies
    • 14
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Quelle
    • 34
    • 6
    • 2
    • 1
    Escherichia coli (E. coli)
    Applikation
    Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
    Spezifität
    Optimal preservation of protein structure, post-translational modifications and functions.
    Produktmerkmale
    • Recombinant human BMP4 (transcript variant 1) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Reinheit
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin-Niveau
    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
    Biological Activity Comment
    Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
    Handhabung
    Resuspend the protein in the desired concentration in proper buffer
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    BMP4 (Bone Morphogenetic Protein 4 (BMP4))
    Andere Bezeichnung
    Bmp4 (BMP4 Produkte)
    Synonyme
    BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, Bmp-4, Bmp2b, Bmp2b-1, Bmp2b1, BOMPR4A, bmp-4, zbmp-4, zgc:100779, BMP-4, XBMP-4, bmp2b, bmp2b1, bmp4, ofc11, xbmp4, zyme, BMP4, bone morphogenetic protein 4, bone morphogenetic protein 4 L homeolog, bone morphogenetic protein 4 S homeolog, BMP4, Bmp4, bmp4, bmp4.L, bmp4.S
    Hintergrund
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
    Molekulargewicht
    12 kDa
    NCBI Accession
    NP_001193
    Pathways
    Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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