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BAG4 Protein (BCL2-Associated Athanogene 4) (Myc-DYKDDDDK Tag)

BAG4 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2715136
$1,112.40
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
20 μg
Lieferung in 11 Werktagen
  • Target Alle BAG4 Proteine anzeigen
    BAG4 (BCL2-Associated Athanogene 4 (BAG4))
    Protein-Typ
    Recombinant
    Spezies
    • 3
    • 2
    • 1
    Human
    Quelle
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses BAG4 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human BAG4 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    BAG4 (BCL2-Associated Athanogene 4 (BAG4))
    Andere Bezeichnung
    Bag4 (BAG4 Produkte)
    Synonyme
    BAG-4, SODD, BAG4, fd20a04, wu:fd20a04, si:dkey-220o5.3, 2410112I15Rik, ATBAG4, BCL-2-associated athanogene 4, BCL2 associated athanogene 4, BCL2-associated athanogene 4, BCL-2-associated athanogene 4, BAG4, Bag4, bag4
    Hintergrund
    The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
    Molekulargewicht
    49.4 kDa
    NCBI Accession
    NP_004865
    Pathways
    Regulation of Actin Filament Polymerization
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