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WRNIP1 Protein (Werner Helicase Interacting Protein 1) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

WRNIP1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2715072
$1,019.70
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
20 μg
Lieferung in 11 Werktagen
  • Target Alle WRNIP1 Proteine anzeigen
    WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Transcript Variant 2
    Spezies
    • 1
    • 1
    Human
    Quelle
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses WRNIP1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human ATPase WRNIP1 (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))
    Andere Bezeichnung
    Atpase Wrnip1 (WRNIP1 Produkte)
    Synonyme
    WRNIP1, wrnip1, RP11-420G6.2, WHIP, bA420G6.2, zgc:85976, 4833444L21Rik, Wrnip, Whip, Werner helicase interacting protein 1, Werner helicase interacting protein 1 L homeolog, ATPase WRNIP1, WRNIP1, wrnip1.L, wrnip1, EDI_075920, CpipJ_CPIJ017857, PITG_07216, VDBG_02914, Wrnip1, PGTG_08805
    Hintergrund
    Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
    Molekulargewicht
    69.3 kDa
    NCBI Accession
    NP_569079
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