APEX1 Protein (Apurinic/Apyrimidinic Endonuclease 1) (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2714787

Produktdetails

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 3

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses APEX1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human APEX1 / REF-1 (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Andere Bezeichnung: Apex1,ref-1 (APEX1 Produkte)

Synonyme: apex1, MGC76280, MGC79645, MGC78928, APE, APE1, APEN, APEX, APX, HAP1, REF1, Apex, REF-1, BAP1, apex1a, hm:zehn1532, wu:fc13d11, zgc:66204, Ref-1, apurinic/apyrimidinic endodeoxyribonuclease 1, APEX nuclease (multifunctional DNA repair enzyme) 1, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog, DNA-(apurinic or apyrimidinic site) lyase, apurinic/apyrimidinic endonuclease 1, APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1

Hintergrund: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene all encode the same protein.

Molekulargewicht: 35.4 kDa

NCBI Accession: NP_542380

Pathways: DNA Reparatur, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus