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APP Protein (Amyloid beta (A4) Precursor Protein) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

APP Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Pubmed (1 reference)
Produktnummer ABIN2714676
$1,019.70
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
20 μg
Lieferung in 11 Werktagen
  • Target Alle APP Proteine anzeigen
    APP (Amyloid beta (A4) Precursor Protein (APP))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Transcript Variant 2
    Spezies
    • 20
    • 15
    • 3
    Human
    Quelle
    • 24
    • 8
    • 3
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses APP Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human Amyloid beta A4 protein / APP (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Planque, Nishiyama, Sonoda, Lin, Taguchi, Hara, Kolodziej, Mitsuda, Gonzalez, Sait, Fukuchi, Massey, Friedland, ONuallain, Sigurdsson, Paul: "Specific amyloid β clearance by a catalytic antibody construct." in: The Journal of biological chemistry, Vol. 290, Issue 16, pp. 10229-41, (2015) (PubMed).

  • Target
    APP (Amyloid beta (A4) Precursor Protein (APP))
    Andere Bezeichnung
    Amyloid beta a4 Protein,app (APP Produkte)
    Synonyme
    AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Rex-1, Rex1, Zfp-42, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740, amyloid beta precursor protein, zinc finger protein 42, amyloid beta (A4) precursor protein, beta amyloid protein precursor-like, amyloid beta (A4) precursor protein a, amyloid beta precursor protein L homeolog, APP, Zfp42, app, Appl, App, appa, app.L
    Hintergrund
    This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
    Molekulargewicht
    83 kDa
    NCBI Accession
    NP_958816
    Pathways
    Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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