A2ML1 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2714611

Dieses Recombinant A2ML1-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für A2ML1 Protein (Myc-DYKDDDDK Tag) (ABIN2714611)

Target: A2ML1 (alpha-2-Macroglobulin-Like 1 (A2ML1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Antibody Production (AbP), Standard (STD)

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Produktdetails

Aufreinigungstag / Konjugat: Dieses A2ML1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Produktmerkmale:

• Recombinant human Alpha-2-macroglobulin-like 1 (A2ML1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: A2ML1 (alpha-2-Macroglobulin-Like 1 (A2ML1))

Hintergrund: This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 161 kDa

NCBI Accession: NP_653271