P-Cadherin Protein (CDH3) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2713023

Produktdetails

Target: P-Cadherin (CDH3)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses P-Cadherin Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Cadherin-3 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Referenzen

Broussard, Kim, Wiley, Marquez, Annis, Pritchard, Disis: "Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions." in: Cancer prevention research (Philadelphia, Pa.), Vol. 6, Issue 7, pp. 666-74, (2013) (PubMed).

Antigendetails

Target: P-Cadherin (CDH3)

Andere Bezeichnung: Cadherin-3 (CDH3 Produkte)

Synonyme: CDH3 Protein, Cadherin-3 Protein, AI385538 Protein, Cadp Protein, Cdhp Protein, P-cadherin Protein, Pcad Protein, CDHP Protein, HJMD Protein, PCAD Protein, E-Cad Protein, E-cadherin Protein, EP-cadherin Protein, XTCAD-1 Protein, c-cadherin Protein, cadherin-1 Protein, cdh1 Protein, cdh1-b Protein, cdh3 Protein, cdhc-A Protein, cdhp Protein, hjmd Protein, l-cam Protein, lcam Protein, pcad Protein, uvo Protein, uvomorulin Protein, xb-cad Protein, xcdh1 Protein, CDH15 Protein, K-CAM Protein, cadherin 3 Protein, cadherin 3 L homeolog Protein, Cadherin-3 Protein, CDH3 Protein, Cdh3 Protein, cdh3.L Protein, cdh-3 Protein

Hintergrund: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS).

Molekulargewicht: 88.8 kDa

NCBI Accession: NP_001784