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Histone H3.1 Protein (HIST1H3B) (biotinylated, C-Term, full length)

HIST1H3B Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant EAA, ScA
Produktnummer ABIN2669582
  • Target Alle Histone H3.1 (HIST1H3B) Proteine anzeigen
    Histone H3.1 (HIST1H3B)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    C-Term, biotinylated, full length
    Spezies
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 4
    • 2
    Escherichia coli (E. coli)
    Applikation
    Enzyme Activity Assay (EAA), Screening Assay (ScA)
    Produktmerkmale
    Recombinant Histone H3.1 - biotinylated, Human, corresponds to the native histone sequence of mammalian histone H3 variant H3.1 and does not contain any amino acid substitutions or residue analogs. Histone H3.1 is known to be important for gene regulation. Recombinant Histone H3.1 - biotinylated, Human consists of the full-length sequence of human Histone H3.1 variant (accession number NM_003529) and contains a C-terminal Biotin-tag. Recombinant Histone H3.1 - biotinylated, Human was generated in E. coli cells and has an observed molecular weight of 18 kDa.
    Top Product
    Discover our top product HIST1H3B Protein
  • Applikationshinweise
    Recombinant Histone H3.1 - biotinylated, Human is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 μg/μL
    Handhabung
    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
  • Target
    Histone H3.1 (HIST1H3B)
    Andere Bezeichnung
    Histone H3.1 (HIST1H3B Produkte)
    Synonyme
    H3 histone Protein, Hist1h2ai Protein, histone cluster 1, H2ai-like1 Protein, histone H3.1 Protein, Hht21p Protein, Hist1h2ail1 Protein, H3.1 Protein, HHT21 Protein
    Hintergrund
    Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 146 base pairs of DNA wrapped around an octamer of core histone proteins (two each of H2A, H2B, H3 and H4). Histone H1 is a linker protein, present at the interface between the nucleosome core and DNA entry/exit points. Histone H3.1 and Histone H3.3 are the two main Histone H3 variants found in plants and animals. They are known to be important for gene regulation. Histone H3.1 and H3.3 have been shown to demonstrate unique genomic localization patterns thought to be associated with their specific functions in regulation of gene activity. Specifically, Histone H3.1 localization is found to coincide with genomic regions containing chromatin repressive marks (H3K9me3, H3K27me3 and DNA methylation), whereas Histone H3.3 primarily colocalizes with marks associated with gene activation (H3K4me3, H2BK120ub1, and RNA pol II occupancy). Deposition of the Histone H3.1 variant into the nucleosome correlates with the canonical DNA synthesis-dependent deposition pathway, whereas Histone H3.3 primarily serves as the replacement Histone H3 variant outside of S-phase, such as during gene transcription. Aberrant localization of these variants is also known to correlate with certain cancers.
    Molekulargewicht
    18 kDa
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