Nef Protein

Produktnummer ABIN2669326

Dieses Recombinant Nef-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Nef Protein (ABIN2669326)

Target: Nef

Protein-Typ: Recombinant

Spezies: Human Immunodeficiency Virus (HIV)

Quelle: Escherichia coli (E. coli)

Applikation: Endotoxin Detection Assay (EDA), High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)

Reinheit: >90 %

Produktdetails

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: The protein should be reconstituted in apirogenic sterile water or 1X PBS.

Buffer: 1 % glycerol

Lagerung: 4 °C

Antigendetails

Target: Nef

Substanzklasse: Viral Protein

Hintergrund: HIV-1 Nef is a 27 kDa protein abundantly produced shortly after virus infection. Nef is an essential factor for efficient viral replication and pathogenesis, it also facilitates virus replication and enhances virions infectivity. Nef exerts pleiotropic effects: down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK, protects the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. Nef protein bypasses host T-cell signaling by inducing a trascriptional program nearly identical to that of anti-CD3 cell activation.