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DLL1 Protein

Recombinant DLL1-Protein exprimiert in HEK-293 Cells.
Produktnummer ABIN2469061

Kurzübersicht für DLL1 Protein (ABIN2469061)

Target

Alle DLL1 Proteine anzeigen
DLL1 (delta-Like 1 (DLL1))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 13
  • 3
  • 2
Human, Ratte

Quelle

  • 9
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

< 95 % by SDS-PAGE gel and HPLC analyses.
  • Sequenz

    SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEEWSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FTCGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNGG SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSPDGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGRNCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF

    Produktmerkmale

    Biological activity was determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP - 1. sDLL - 1 inhibits the proliferation in THP - 1 cells using a concentration of 3.0 - 5.0 μg/mL.

    Endotoxin-Niveau

    Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Handhabung

    As with any protein, exposing sDLL-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted sDLL-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.

    Haltbarkeit

    24 months
  • Target

    DLL1 (delta-Like 1 (DLL1))

    Andere Bezeichnung

    sDLL-1

    Hintergrund

    Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK cell precursors. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues.

    Gen-ID

    24772

    NCBI Accession

    NP_001029054

    OMIM

    76496504

    UniProt

    Q9QZD1

    Pathways

    Notch Signalweg, Stem Cell Maintenance
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