DLL1 Protein
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- Target Alle DLL1 Proteine anzeigen
- DLL1 (delta-Like 1 (DLL1))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human, Ratte
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Quelle
- HEK-293 Cells
- Sequenz
- SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEEWSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FTCGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNGG SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSPDGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGRNCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF
- Produktmerkmale
- Biological activity was determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP - 1. sDLL - 1 inhibits the proliferation in THP - 1 cells using a concentration of 3.0 - 5.0 μg/mL.
- Reinheit
- < 95 % by SDS-PAGE gel and HPLC analyses.
- Endotoxin-Niveau
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
- Top Product
- Discover our top product DLL1 Protein
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delta-Like 1 (DLL1) (AA 18-540) protein (His tag)
DLL1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 1 (DLL1) protein (Fc Tag)DLL1 Spezies: Human Wirt: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
delta-Like 1 (DLL1) (Active) protein (His tag)DLL1 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
delta-Like 1 (DLL1) (AA 18-545) (Active) protein (Fc Tag)DLL1 Spezies: Human Wirt: CHO Cells Recombinant >90 % (SDS-PAGE) SDS Active
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Handhabung
- As with any protein, exposing sDLL-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted sDLL-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- Haltbarkeit
- 24 months
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- Target
- DLL1 (delta-Like 1 (DLL1))
- Andere Bezeichnung
- sDLL-1 (DLL1 Produkte)
- Hintergrund
- Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK cell precursors. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues.
- Gen-ID
- 24772
- NCBI Accession
- NP_001029054
- OMIM
- 76496504
- UniProt
- Q9QZD1
- Pathways
- Notch Signalweg, Stem Cell Maintenance
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