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Insulin-Like Growth Factor 2 (IGF2) (AA 25-91) (Active) protein (Fc Tag) Protein

IGF2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181264
$220.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle IGF2 Proteine anzeigen
    IGF2
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 25-91
    Spezies
    • 17
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Quelle
    • 25
    • 8
    • 3
    • 3
    • 3
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses IGF2 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 25-91
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 35 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    IGF2
    Andere Bezeichnung
    IGF-II (IGF2 Produkte)
    Synonyme
    C11orf43, IGF-II, PP9974, LOC100136550, igf2, igf2b, wu:fc26e03, zgc:91781, igf-2, insigf, pp9974, AL033362, Igf-2, Igf-II, M6pr, Mpr, Peg2, IGFII, RNIGF2, IGF-II-B, igf2-a, igf2-b, insulin like growth factor 2, insulin-like growth factor II, insulin-like growth factor 2a, insulin like growth factor 2 S homeolog, insulin-like growth factor 2, insulin-like growth factor 2 (somatomedin A), insulin like growth factor 2 L homeolog, IGF2, LOC100136550, igf2a, igf2.S, Igf2, igf2.L
    Hintergrund
    Insulin-like growth factor 2 (IGF-2) is also known as Somatomedin-A, IGF-II, PP9974, and is one of three protein hormones that share structural similarity to insulin. IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signalling antagonist, that is, to prevent IGF2 responses. The major role of IGF2 is as a growth promoting hormone during gestation. In the process of Folliculogenesis, IGF2 is created by Theca cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on Granulosa cells in the ovary. IGF2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting alongside Follicle Stimulating Hormone (FSH). After ovulation has occurred, IGF-2 promotes progesterone secretion during the luteal phase of the menstrual cycle together with Luteinizing Hormone (LH). Thus, IGF2 acts as a Co-hormone together with both FSH and LH. IGF-2 may play a key role in memory and could potentially be used to treat Alzheimer's Disease. It is sometimes produced in excess in islet cell tumours, causing hypoglycemia. Doege-Potter syndrome is a paraneoplastic syndrome in which hypoglycemia is associated with the presence of one or more non-islet fibrous tumors in the pleural cavity. has been shown to interact with IGFBP3 and Transferrin.
    Molekulargewicht
    34.4 kDa
    Pathways
    Hormone Activity, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Activated T Cell Proliferation
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