ICOSLG Protein (AA 19-258) (His tag)

Produktnummer ABIN2181242

Dieses Recombinant ICOSLG-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für ICOSLG Protein (AA 19-258) (His tag) (ABIN2181242)

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: >95 % as determined by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 19-258

Aufreinigungstag / Konjugat: Dieses ICOSLG Protein ist gelabelt mit His tag.

Sequenz: AA 19-258

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.5 kDa. The protein migrates as 35-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Antigendetails

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Andere Bezeichnung: B7-H2

Hintergrund: ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Molekulargewicht: 27.8 kDa

NCBI Accession: NP_056074

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation