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Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 25-621) (Active) protein (Fc Tag) Protein

CSF3R Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181147
$319.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle CSF3R Proteine anzeigen
    CSF3R
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 25-621
    Spezies
    • 12
    • 4
    • 2
    Human
    Quelle
    • 7
    • 6
    • 3
    • 2
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CSF3R Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 25-621
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.8 kDa. The protein migrates as 100-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    CSF3R
    Andere Bezeichnung
    G-CSF R (CSF3R Produkte)
    Synonyme
    CD114, GCSFR, Cd114, Csfgr, G-CSF-R, G-CSFR, CSF3R, gcsfr, cd114, colony stimulating factor 3 receptor, colony stimulating factor 3 receptor (granulocyte), colony stimulating factor 3 receptor L homeolog, granulocyte colony-stimulating factor receptor, CSF3R, Csf3r, csf3r, csf3r.L, LOC100433338
    Hintergrund
    Granulocyte Colony Stimulating Factor Receptor (G-CSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I  membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.
    Molekulargewicht
    92.7 kDa
    NCBI Accession
    NP_000751
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