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Fc gamma Receptor and Transporter (FCGRT) (AA 24-297) (Active) protein (His tag,Strep Tag) Protein

FCGRT Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed (6 Referenzen)
Produktnummer ABIN2181085
$385.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle FcRn (FCGRT) Proteine anzeigen
    FcRn (FCGRT)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 24-297
    Spezies
    • 11
    • 4
    • 4
    • 3
    • 2
    • 1
    Human
    Quelle
    • 12
    • 4
    • 3
    • 3
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses FcRn Protein ist gelabelt mit His tag,Strep Tag.
    Marke
    MABSol®
    Sequenz
    AA 24-297
    Produktmerkmale
    Human FcRn / FCGRT & B2M heterodimer protein, produced by co-expression of FCGRT and B2M, has a calculated MW of 31.2 kDa FCGRT and 13.1 kDa (B2M). Subunit FCGRT is fused with his-tag at the C-terminus and subunit Beta-2 microglobulin (B2M) is fused with Strep II-tag at the C-terminus. The predicted N-terminus is Ala 24(FCGRT) & Ile 21(B2M). The reducing (R) protein migrates as 33 kDa (FCGRT) and 13 kDa (B2M) respectively due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Kisalu, Pereira, Ernste, Flores-Garcia, Idris, Asokan, Dillon, MacDonald, Shi, Chen, Pegu, Schön, Zavala, Balazs, Francica, Seder: "Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention." in: JCI insight, Vol. 6, Issue 3, (2021) (PubMed).

    Zhao, Gao, Yu, Li, Zhang, Zhang, Lu, Gao, Guo: "Unidirectional transport of IgG by neonatal Fc receptor in human thyrocytes varies across different IgG subclasses." in: Molecular and cellular endocrinology, Vol. 477, pp. 103-111, (2019) (PubMed).

    Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).

    Yang, Kim, Seong, Tae, Kwon: "Comparative studies of the serum half-life extension of a protein via site-specific conjugation to a species-matched or -mismatched albumin." in: Biomaterials science, Vol. 6, Issue 8, pp. 2092-2100, (2018) (PubMed).

    Zhou, Wang, Tong, Okamoto, Shen, Zaro: "Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery." in: Biomaterials, Vol. 117, pp. 24-31, (2017) (PubMed).

    Kenniston, Taylor, Conley, Cosic, Kopacz, Lindberg, Comeau, Atkins, Bullen, TenHoor, Adelman, Sexton, Edwards, Nixon: "Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody." in: The Journal of biological chemistry, Vol. 292, Issue 42, pp. 17449-17460, (2017) (PubMed).

  • Target
    FcRn (FCGRT)
    Andere Bezeichnung
    FcRn (FCGRT Produkte)
    Synonyme
    FCRN, alpha-chain, FcRn, Fc fragment of IgG receptor and transporter, Fc receptor, IgG, alpha chain transporter, FCGRT, Fcgrt
    Sub Type
    Fusionprotein
    Hintergrund
    FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
    Molekulargewicht
    31.2 kDa (FCGRT) & 13.1 kDa (B2M)
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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