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CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-159) protein (Fc Tag) Protein

CD79B Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Pubmed (1 reference)
Produktnummer ABIN2180837
$319.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle CD79b (CD79B) Proteine anzeigen
    CD79b (CD79B)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 29-159
    Spezies
    • 12
    • 4
    • 2
    • 2
    • 2
    Human
    Quelle
    • 10
    • 4
    • 3
    • 3
    • 2
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD79b Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 29-159
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.8 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 0.1 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Ding, Mao, Cao, Wang, Xu, Zhou: "Targeting CD79b for Chimeric Antigen Receptor T-Cell Therapy of B-Cell Lymphomas." in: Targeted oncology, Vol. 15, Issue 3, pp. 365-375, (2020) (PubMed).

  • Target
    CD79b (CD79B)
    Andere Bezeichnung
    CD79B (CD79B Produkte)
    Synonyme
    B29, Ig-beta, Igb, Igbeta, AGM6, IGB, CD79B antigen, CD79b molecule, Cd79b, CD79B
    Hintergrund
    B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
    Molekulargewicht
    41.8 kDa
    NCBI Accession
    NP_000617
    Pathways
    BCR Signaling
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